A virus has decimated humankind. Those who survived emerged blind. Centuries later when twins are born with the mythic ability to see, their father must protect his tribe against a threatened queen.

Hundreds of years from now, surviving humans discover how to send consciousness back through time, into people of the 21st century, while attempting to save humanity from a terrible future.

Five years after the public became aware of the existence of evolved humans - or EVOs. Said public is not entirely supportive of these EVOs. In fact, few people fall into the middle ground. Online, a community forms around the rallying cry of the anonymous Hero_Truther, who seeks to humanize EVOs in the wake of lies, slander and fear mongering. Among those posting their personal stories is Phoebe Frady, who is encouraged to document her origin story by her brother, Quentin. But as Phoebe struggles to control her power, she attracts unwanted attention from a mysterious new company.

The series centers around brother and sister team Juni and Carmen Cortez as they attend Spy Kids Academy, a top secret spy school for kid agents. When a new counter-spy agency threatens the safety of the world, it will be up to junior spies Juni and Carmen to train and lead a team of fellow Spy Kids cadets against the forces of S.W.A.M.P. (Sinister Wrongdoers Against Mankind's Preservation) and their diabolical leader, Golden Brain. The Mission Critical team may not be ready, but they are the only ones to call when grown-up spies can't do the job.